Molecular pump controlled by fluctuations of electric field
Анотація
Transport of particles through biological membranes, guided by fluctuations of the electric field, is examined. A model is considered supposing the particles to be carried along the channels of a membrane, which conformations are sensitive to the influence of the external electric field. Fluctuations of the electric field causing the conformation changes of the channel, combined with the processes of capture of the particles from solution on one side of the membrane and their liberation on the other side of it, cause a circulatory current which determines the functioning rate of the molecular pump. For the arbitrary values of rate constants of transitions between the states of the system, dependences of the current on the frequency and the amplitude of the applied field are calculated. It is shown that the maximum current will be realized in a frequency interval between characteristic frequencies of capture/liberation of particles and conformation changes of channel. Efficiency of transformation of the electric field energy into the energy of the unidirectional transport of particles through a membrane against the gradient of concentrations is discussed.
Посилання
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