Modification of surface of finely dispersed magnetic powders with the purpose to create medical materials

O. M. Fedorenko; N. I. Shklovskaya; G. T. Kurbatova; S. T. Sokhov; I. A. Verholomova

O. M. Fedorenko Інститут хімії поверхні НАН України
N. I. Shklovskaya Інститут хімії поверхні НАН України
G. T. Kurbatova Інститут хімії поверхні НАН України
S. T. Sokhov Stavropol State Medical Academy
I. A. Verholomova Stavropol State Medical Academy

Анотація

Processes of production of cross-linked polyacrylamide and dextran coating on the FDIP - (finely disperse iron powders) surface have been studied with the use of complex of physical and chemical methods of IR-, XPE-spectroscopy and X-ray phase analysis. While forming a polyacrylamide layer on the FDIP surface in photopolymerisation reaction, a process occurs concurrently which leads to ion-radical forms of oxygen adsorption on magnetic particles, that is manifested in IR spectrum by an intense doublet of bands is 1080 and 1120 cm^-1, as well as a transfer of proton of hydroxyl groups of the FDIP surface to a nitrogen atom of polyacrylamide, that is due to appearance of the component 401.0 eV in XPE spectrs of N1s-photoelectrons, corresponding to a NH⁺ group. During production of the coating of cross-linked dextran on the FDIP surface it was found a formation of complex between ions of iron locating on an outer surface of the stabilizing coating having oxygen-containing groups of the dextran coating, that is supported by a shift of absorption bands of oxygen-containing groups into a long-wave number region, as well as emergence of two new components with bond energies of 709.2 and 712.2 eV in XPE spectruum of Fe2p-photoelectrons.

Directed delivery and distribution of anaesthetics (novocaine, lidocaine, trimecaine) immobilized on FDIP under the influence of an external magnetic field in body tissues of test animals have been studied. The data of emission spectral analysis relating to concentration of iron in soft and bone tissues of animals influenced by constant and alternating magnetic field on the front and rear sides over a period from 0 to 180 min are given.

Посилання

Hafeli U., Schüt W., Teller J., Zborowski N. Scientific and Clinical Applications of magnetic Carriers. - N. Y. - L.: Penum Press, 1997. - 628 p.

Physycal principles for the application of ferromagnetics./ Rymarchuk V.I., Malenkov A.G., Radkevich L.A., Sarbash V.I. // Biophisics. - 1990. - V.35, N1. - P. 145- 154.(in Russian)

Surface structure of finely dispersed iron powders 1. Formation of stabilizing coating / Mikhailik O.M., Povstugar V.I., Mikhailova S.S., Lyakhovich A.M., Fedorenko O.M., Kurbatova G.T., Shklovskaya N.I., Chuiko A.A.//Colloids and Surfaces.- 1991.-V.52- P.315-324.

Patent 25046 A61K 9/50. Microcapsule. Publ.25.12.1998.// N.I.Shklovskaya, S.T.Sokhov, O.M.Fedorenko Kurbatova G.T., Verholomova I.A., Guliy L.I., Chuiko A. A., Melnik L. V., Baklan S. V.

A study of the process of the formation polyakrylamide coating on the finely dispersed iron powders surface / Chuiko A.A., Fedorenko O.M., Kurbatova G.T., Fesenko T V, Shklovskaya N.I. //Dop.of NAS of Ukraine -2000 -N9 -P.156-161. (in Russian).

Tarutina L.I., Pozdniakova F 0. Spectral analysis of polymers and supplementary substances. - L.: Khimiya 1986,- 261 p.(in Russian).

Jurchenko E.N , Kustova G.N., Batsanov S. S. Vibrational spectra of inorganic substances.- M. 1981 - 144 p.(in Russian).

Nakamoto K. Infrared and Raman Spectra and Spectra KR of Inorganic and Coordination Compounds.- M.:Mir, 1991. - 505 p.

Davidov A. A., Shepotko M.A. / IR spectra of the NH₃, CO and NO adsorbed on the a-Fe₂O₃ and the nature of the active sites of the oxide // J. Applied. Spectr. - 1992 - V.56, N3. - P.487-490.(in Russian),

Davidov A.A. / State and reaction ability of oxygen on the surface of stanum oxide as studied by IR spectroscopy. // J. Applied spectr. - 1992. - V.56, N4. - P.597-605. (in Russian).

Fotosensitized formation of singlet oxygen by B-group vitamins / Dzhagarov V.M., Kruk N.N., Konovalova N.B., Solodunov A.A., Stepurko I.I. // J. Applied Spectr. -1995. - V.62, N2. - P. 122-127.(in Russian).

Handbook of X-ray photoelectron spectroscopy. Physical electronics Division. - 1992.-261 p.

Pomogailo A.D , Savostianov V S. Metal-containing monomers and polymers on their basis - M.: Khimiya, 1988, -324 p

Zhbankov R G. Infrared spectra and structure of carbohydrates. - Minsk: Nauka i technika, 1972 - 180 c.

Phakadze G.A. Biodestructive Polymers. - Kiev: Naukova dumka. - 1990. - 159 p.

Preparation hydrolytic stability iron - dextrane particles / Kurbatova G.T., Mikhailik O.M., Oranskaya E.I., Shklovskaya N.I. // Ukr. Chem. Zhurn. - 1994. - V.60, N2. - P. 141-145.(in Russian).

Kiselov V.P., Komar V.P., Skornjakov I.V. / Spectroscopic study of different structure modifications of dexstrane // Vysokomolec. Soed - 1977. - V.19, N8. - P.1867-1872. (in Russian).

Andrianov V.M., Zhbankov R.G., Daschevsky V.G. / Vibrational spectra for hexopyranose ring of the epoxysaccharide // Struct.Chem. - 1980. - 21, N4. - P.35-42. (in Russian).

Andrianov V.M., KirilovaS.G., Zhbankov R.G. / Vibrational spectra for hexopyranose ring of the epoxysaccharide //J. Struct. Chem,-1995.-36, N2.- P.330-337 (in Russian).

Korolevich M.V., Zhbankov R.G. / Vibrational spectra for hexopyranose ring of the epoxysaccharide // J. Struct. Chem. - 1997. - 64, N6. - P.724-728. (in Russian).

21 Comparison of polysaccharide iron complex used as iron supplements / Coe E.M., Boven L.H., Speer J.A., Bereman R.D. // J. Inorg. Biochem. - 1995. - V.57, N 4. - P.287- 292.

Fedorenko O.M., Oranskaya E. I. Shklovskaya N.I. / A spectroscopic study of the structure of the surface layer of modified finely dispersed iron powders // J.Appl, Spectroscop. - 1994. - V.61, N 5-6. - P.447-454.(in Russian).

Suschko N.I., Firsov S.P., Zhbankov R.G., Tsarenkov V.M. The method of production thin structure IR-spectrum of geparine and there interpretation // J.Appl.Spectr. 1993. - V.59, N 1-2. - P.49-53. (in Russian).

Davis S.S. / Drug Targeting // Manufacturing Chemist. - 1986. -V. 57, N 1. - P.42-45.

Ruuge E.K., Rusetskii A N, / Magnetically drug targeting // Zhurn, Vses. Khim.Obsh, -1987.-32, N5,-P 556-561

Mavrichev A.S., Fertman V. Ye // Vopr Oncol. - 1991. - V.37, N 1. - P. 11-17. (in Russian).

Sugibayashi K., Morimoto Y. Polymeric Nanoparticulates and Microsperes. Boca Ration FL, 1986. - P.175-198.

Ternovoi K.S., Derzhavin. / Distibution and removal of magnetic Microcarriers of the antitumour drugs from the body // Eksp. Oncol. - 1984. - V.6, N 5. -P.66-69.(in Russian).

Baribin A.S., Retschikov V.P. / The of permanent magnets and magnetic fluids in experimental oncology//Eksp. Oncol. -1985. - V.7, N4. - P. 18-24.(in Russian).

Federov Y.I., Ivanenko G.F, Burlakova Y.B / Effect of a higtly-dispersed iron powders on the life span of irradiated animals // Radiobiologia. - 1984. - V.24, N 1. - P. 104-108. (in Russian).

Change of ferromagnetic suspension in animal organism. / Tsapin A.I.,Dvukhsherstnov S.D., Malenkov A G, Vanin A.F. //Biofisika. - 1986, - V.31. -P.1023- 1026.(in Russian).

Biological influence finely dispersed iron powders / Glushcenko N.N, Olkhovskaya I.P, Pletneva T.V. Faktulina L.D, Ershov Y. A, Fedorov Y.I. // Izvest. Akad. Nauk. USSR Ser. Biol. - 1989. - V.32, N3. - P.415-421. (in Russian).

Ternovoi K.S, Derzavin A Y. / Magnetically controllable drugs. Theoretical and experimental basis // Eksp. Onkol. - 1984. - V.4, N6. - P.66-71.(in Russian).

The distribution of anaesthetics, immobilized in higtly dispers iron powders, in the body of experimental animals / Kurbatova G.T, Fedorenko O.M, Sokhov S.T, Verholomova I. A, Shklovskaya N.I. // Biofizika. - 1997. - V.42, N 6. - P. 1327-1332. (in Russian).

Pilipenko A.T., Pyatnitskii.I.V. Analytical Chemistry. - Vol. 2. - Moscow: Khimia, 1990.-348 p.